Dérivés de N-(2-pyrrolidinylméthyl)benzamide, leur procédé de préparation, intermédiaires et médicaments les contenant

Derivatives of N-(2-pyrrolidinylmethyl)-benzamide, process for their preparation, intermediates and a pharmaceutical preparation

Derivate von N-(2-Pyrrolidinylmethyl)benzamid, Verfahren zu ihrer Herstellung, Zwischenprodukte und pharmazeutische Zubereitung


Novel therapeutically active compounds of the formula wherein Z , being Z 1 , Z 2 or Z 3 , is the same or different and selected among OH, OR', NH 2 , NR 2 4 , NHR', SH, SR 4 and OR 4 wherein R' is a formyl group, an acyl group, an alkoxycarbonyl group or a mono- or dialkylcarbamoyl group and R 4 is a lower alkyl group, R 2 is a hydrogen, a halogen, a lower alkyl or a lower trifluoroalkyl group, R 3 is a hydrogen atom, a lower alkyl group, an alkenyl group, an alkynyl group or a phenyl group, which phenyl group could optionally be substituted by one or more of fluoro, chloro, bromo, trifluoromethyl, methyl, ethyl, methoxy or ethoxy in the ortho, meta or para positions, or optionally substituted by methylenedioxy, provided that at least one of Z 1 , Z 2 and Z 3 is a group OR 4 and further provided that when Z 2 is OH or NH 2 , Z' is NR 2 4 , NHR 4 , SH, SR 4 or OR' or a physiologically acceptable salt or optical isomer thereof, intermediates and methods for their preparation, pharmaceutical preparations containing the compounds and methods for their therapeutical use.




Download Full PDF Version (Non-Commercial Use)

Patent Citations (3)

    Publication numberPublication dateAssigneeTitle
    EP-0004831-A2October 17, 1979Astra Läkemedel Aktiebolag2,6-Dialkoxybenzamides, procédés pour leur préparation, compositions et ces produits pour leur utilisation dans le traitement des psychoses
    EP-0060235-A1September 15, 1982Astra Läkemedel AktiebolagDérivés de la benzamide
    EP-0117384-A1September 05, 1984Astra Läkemedel AktiebolagN-(1-Ethyl-2-pyrrolidinylmethyl)-benzamid-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen

NO-Patent Citations (0)


Cited By (1)

    Publication numberPublication dateAssigneeTitle
    US-5446147-AAugust 29, 1995Trustees Of The University Of PennsylvaniaFluorinated and iodinated dopamine agents